ParkinsonCanadaV1, Main, Exploration, bibRecord, 001948

Epidemiology and etiology of Parkinson's disease: a review of the evidence

Identifieur interne : 001948 ( Main/Exploration ); précédent : 001947; suivant : 001949

Epidemiology and etiology of Parkinson's disease: a review of the evidence

Auteurs : Karin Wirdefeldt [Suède, États-Unis] ; Hans-Olov Adami [Suède] ; Philip Cole [États-Unis] ; Dimitrios Trichopoulos [États-Unis] ; Jack Mandel [Canada]

Source :

European journal of epidemiology [ 0393-2990 ] ; 2011.

RBID : Pascal:11-0275440

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Epidémiologie, Santé publique, Etiologie, Revue bibliographique, Article synthèse, Facteur risque, Homme.
Wicri :
- topic : Santé publique, Homme.

English descriptors

KwdEn :
- Bibliographic review, Epidemiology, Etiology, Human, Parkinson disease, Public health, Review, Risk factor.

Abstract

The etiology of Parkinson's disease (PD) is not well understood but likely to involve both genetic and environmental factors. Incidence and prevalence estimates vary to a large extent-at least partly due to methodological differences between studies-but are consistently higher in men than in women. Several genes that cause familial as well as sporadic PD have been identified and familial aggregation studies support a genetic component. Despite a vast literature on lifestyle and environmental possible risk or protection factors, consistent findings are few. There is compelling evidence for protective effects of smoking and coffee, but the biologic mechanisms for these possibly causal relations are poorly understood. Uric acid also seems to be associated with lower PD risk. Evidence that one or several pesticides increase PD risk is suggestive but further research is needed to identify specific compounds that may play a causal role. Evidence is limited on the role of metals, other chemicals and magnetic fields. Important methodo- logical limitations include crude classification of exposure, low frequency and intensity of exposure, inadequate sample size, potential for confounding, retrospective study designs and lack of consistent diagnostic criteria for PD. Studies that assessed possible shared etiological components between PD and other diseases show that REM sleep behavior disorder and mental illness increase PD risk and that PD patients have lower cancer risk, but methodological concerns exist. Future epidemiologic studies of PD should be large, include detailed quantifications of exposure, and collect information on environmental exposures as well as genetic polymorphisms.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The etiology of Parkinson's disease (PD) is not well understood but likely to involve both genetic and environmental factors. Incidence and prevalence estimates vary to a large extent-at least partly due to methodological differences between studies-but are consistently higher in men than in women. Several genes that cause familial as well as sporadic PD have been identified and familial aggregation studies support a genetic component. Despite a vast literature on lifestyle and environmental possible risk or protection factors, consistent findings are few. There is compelling evidence for protective effects of smoking and coffee, but the biologic mechanisms for these possibly causal relations are poorly understood. Uric acid also seems to be associated with lower PD risk. Evidence that one or several pesticides increase PD risk is suggestive but further research is needed to identify specific compounds that may play a causal role. Evidence is limited on the role of metals, other chemicals and magnetic fields. Important methodo- logical limitations include crude classification of exposure, low frequency and intensity of exposure, inadequate sample size, potential for confounding, retrospective study designs and lack of consistent diagnostic criteria for PD. Studies that assessed possible shared etiological components between PD and other diseases show that REM sleep behavior disorder and mental illness increase PD risk and that PD patients have lower cancer risk, but methodological concerns exist. Future epidemiologic studies of PD should be large, include detailed quantifications of exposure, and collect information on environmental exposures as well as genetic polymorphisms.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Epidemiology and etiology of Parkinson's disease: a review of the evidence

Epidemiology and etiology of Parkinson's disease: a review of the evidence

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri